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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2007 1
2008 1
2010 1
2012 1
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2018 2
2020 1
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2022 1
2024 0

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SEC24A facilitates colocalization and Ca(2)(+) flux between the endoplasmic reticulum and mitochondria.
Chidawanyika T, Chakrabarti R, Beauchemin KS, Higgs HN, Supattapone S. Chidawanyika T, et al. J Cell Sci. 2021 Mar 26;134(6):jcs249276. doi: 10.1242/jcs.249276. J Cell Sci. 2021. PMID: 33622772 Free PMC article.
A genome-wide screen recently identified SEC24A as a novel mediator of thapsigargin-induced cell death in HAP1 cells. ...Knockout of SEC24A, but not its paralogs SEC24B, SEC24C or SEC24D, rescued HAP1 cells from cell death induced by three different inhibitor …
A genome-wide screen recently identified SEC24A as a novel mediator of thapsigargin-induced cell death in HAP1 cells. ...Knockout of …
The ULK1-FBXW5-SEC23B nexus controls autophagy.
Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, Florens L, Washburn MP, Cavasotto CN, Fenyö D, Cuervo AM, Rossi M, Pagano M. Jeong YT, et al. Elife. 2018 Dec 31;7:e42253. doi: 10.7554/eLife.42253. Elife. 2018. PMID: 30596474 Free PMC article.
In response to starvation, ULK1 phosphorylates SEC23B on Serine 186, preventing the interaction of SEC23B with FBXW5 and, therefore, inhibiting SEC23B degradation. Phosphorylated and stabilized SEC23B associates with SEC24A and SEC24B, but not SEC24C and SEC24D, and …
In response to starvation, ULK1 phosphorylates SEC23B on Serine 186, preventing the interaction of SEC23B with FBXW5 and, therefore, inhibit …
The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion.
Deng SJ, Shen Y, Gu HM, Guo S, Wu SR, Zhang DW. Deng SJ, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jun;1865(6):158660. doi: 10.1016/j.bbalip.2020.158660. Epub 2020 Feb 11. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32058034
We also found that natural variants in CTD including S462P, S465L, E482G, R495Q and A522T impaired PCSK9 secretion. Further, the knockdown of SEC24A, SEC24B, SEC24C but not SEC24D reduced secretion of the full-length PCSK9 but not mutant PCSK9(1-446). Therefore, …
We also found that natural variants in CTD including S462P, S465L, E482G, R495Q and A522T impaired PCSK9 secretion. Further, the knockdown o …
SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.
Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D. Chen XW, et al. Elife. 2013 Apr 9;2:e00444. doi: 10.7554/eLife.00444. Elife. 2013. PMID: 23580231 Free PMC article.
Consistent with these data, hepatic LDLR levels are up-regulated in SEC24A-deficient cells as a consequence of specific dependence of PCSK9, a negative regulator of LDLR, on SEC24A for efficient exit from the ER. Our findings also identify partial overlap in cargo s …
Consistent with these data, hepatic LDLR levels are up-regulated in SEC24A-deficient cells as a consequence of specific dependence of …
Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.
Lu CL, Ortmeier S, Brudvig J, Moretti T, Cain J, Boyadjiev SA, Weimer JM, Kim J. Lu CL, et al. Traffic. 2022 Jan;23(1):81-93. doi: 10.1111/tra.12826. Epub 2021 Nov 22. Traffic. 2022. PMID: 34761479 Free PMC article.
There are four SEC24 paralogs (A-D) in vertebrates, which are classified into two subgroups (SEC24A/B and SEC24C/D). Pathological mutations in SEC24D cause osteogenesis imperfecta with craniofacial dysplasia in humans. sec24d mutant fish also recapitulate the phenotypes. . …
There are four SEC24 paralogs (A-D) in vertebrates, which are classified into two subgroups (SEC24A/B and SEC24C/D). Pathological mut …
The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
Wang B, Joo JH, Mount R, Teubner BJW, Krenzer A, Ward AL, Ichhaporia VP, Adams EJ, Khoriaty R, Peters ST, Pruett-Miller SM, Zakharenko SS, Ginsburg D, Kundu M. Wang B, et al. J Clin Invest. 2018 Aug 1;128(8):3319-3332. doi: 10.1172/JCI98194. Epub 2018 Jun 25. J Clin Invest. 2018. PMID: 29939162 Free PMC article.
SEC24 family members are components of the coat protein complex II (COPII) machinery that interact directly with cargo or with other adapters to ensure proper sorting of secretory cargo into COPII vesicles. SEC24C is 1 of 4 mammalian SEC24 paralogs (SEC24A-D), which segreg …
SEC24 family members are components of the coat protein complex II (COPII) machinery that interact directly with cargo or with other adapter …
Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.
Mancias JD, Goldberg J. Mancias JD, et al. EMBO J. 2008 Nov 5;27(21):2918-28. doi: 10.1038/emboj.2008.208. Epub 2008 Oct 9. EMBO J. 2008. PMID: 18843296 Free PMC article.
A conserved IxM packaging signal binds in a surface groove of Sec24c and Sec24d, but the groove is occluded in the Sec24a and Sec24b subunits. Conversely, LxxLE class transport signals and the DxE signal of VSV glycoprotein are selectively bound by Sec24a and …
A conserved IxM packaging signal binds in a surface groove of Sec24c and Sec24d, but the groove is occluded in the Sec24a and Sec2 …
A family of mammalian proteins homologous to yeast Sec24p.
Tang BL, Kausalya J, Low DY, Lock ML, Hong W. Tang BL, et al. Biochem Biophys Res Commun. 1999 May 19;258(3):679-84. doi: 10.1006/bbrc.1999.0574. Biochem Biophys Res Commun. 1999. PMID: 10329445
Database searches and molecular cloning reveal that four different mammalian Sec24p-like proteins exist, all with about 20% amino acid identity with the yeast Sec24p. Sec24A and Sec24B share about 50% amino acid identity. Sec24D is cloned by screening a human pancre …
Database searches and molecular cloning reveal that four different mammalian Sec24p-like proteins exist, all with about 20% amino acid ident …
Mammalian COPII coat component SEC24C is required for embryonic development in mice.
Adams EJ, Chen XW, O'Shea KS, Ginsburg D. Adams EJ, et al. J Biol Chem. 2014 Jul 25;289(30):20858-70. doi: 10.1074/jbc.M114.566687. J Biol Chem. 2014. PMID: 24876386 Free PMC article.
There are four Sec24 paralogs in mammals, with mice deficient in SEC24A, -B, and -D exhibiting a wide range of phenotypes. We now report the characterization of mice with deficiency in the fourth Sec24 paralog, SEC24C. ...The embryonic lethality resulting from loss of SEC2 …
There are four Sec24 paralogs in mammals, with mice deficient in SEC24A, -B, and -D exhibiting a wide range of phenotypes. We now rep …
Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum.
Wendeler MW, Paccaud JP, Hauri HP. Wendeler MW, et al. EMBO Rep. 2007 Mar;8(3):258-64. doi: 10.1038/sj.embor.7400893. Epub 2007 Jan 26. EMBO Rep. 2007. PMID: 17255961 Free PMC article.
By contrast, double knockdown of Sec24A with one of the other three Sec24 isoforms impaired all aromatic/hydrophobic signal-dependent transport. Double knockdown of Sec24B/C or Sec24B/D preferentially affected di-leucine-mediated transport, whereas knockdown …
By contrast, double knockdown of Sec24A with one of the other three Sec24 isoforms impaired all aromatic/hydrophobic signal-dependent …
14 results